Celebrex® is an NSAID used in the treatment of rheumatic disorders. It acts by a specific inhibitory effect on COX-2. The drug blocks the formation of prostaglandins and slightly affects the activity of COX-1. Celebrex® has anti-inflammatory, antipyretic, and analgesic effects.

Composition and form of release

Celebrex is available in capsules of 50 mg, 100 mg, 200 mg, and 400 mg and should be taken with food or milk to avoid stomach irritation. Standard doses range from 200 mg to 400 mg daily, but, in the case of acute gout, the daily dose can be up to 800 mg. Celebrex® is recommended to be taken in minimally effective doses.

Buy Celebrex


Celebrex is indicated for the management of degenerative and inflammatory diseases of the musculoskeletal system (e.g., rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, psoriatic arthritis).


It is forbidden to use Celebrex in the following cases:

  • Hypersensitivity to the components of the drug
  • Hyperergic reactions in the past associated with NSAIDs

  • Bronchial asthma
  • Exacerbation of peptic ulcer of the duodenum/stomach
  • Severe blood clotting disorders
  • Bleeding from the digestive tract
  • Severe heart failure
  • Gastrointestinal bleeding in the past
  • Severe renal/hepatic insufficiency
  • Aortocoronary shunting
  • Severe violations of the heart
  • Childrens

Application in pregnancy and lactation

The drug is contraindicated for use during pregnancy and lactation.

Dosing and administration

Celebrex® is to be taken orally with plenty of liquid. The standard dosage is 200 mg once or twice a day.
The dosage for the treatment of rheumatoid arthritis is 200 mg/day 400 mg/day, divided into two doses.
The use of Celebrex® for pain in the back should be short-lived, i.e., not more than three days.
The drug damages the gastrointestinal mucosa to an extent that is less than the effects of all other NSAIDs, but it can cause a heart attack even in people who are not at risk.


Overdose may demonstrate such symptoms as drowsiness, nausea, and abdominal pain. Gastrointestinal bleeding may occur also.

Side effects

Side effects include abdominal pain, dizziness, nervousness, blurred vision, dyspnea, asthma attacks, anemia, various hypersensitivity reactions, hypertension, nausea, tachycardia, malaise, headaches, vomiting, asthenia, hyperkalemia, drowsiness, nightmares, diarrhea, thrombocytopenia (decrease in the number of blood platelets), constipation, pancytopenia, a sense of fear, purpura, kidney failure, flatulence, itching, hypothermia (fever), hyperhidrosis (increased sweating), skin rashes, hot flashes, bronchospasm, jaundice, dyspepsia, erythema, interstitial nephritis, gastritis, dermatitis, stomatitis, angioedema, bleeding from the digestive tract, urticaria, oliguria, hematuria, facial edema, hepatitis, dysuria, cholestasis, urinary retention, and Stevens–Johnson syndrome.

If any undesirable reactions occur, the patient should stop taking the medication and contact their doctor.

Leave a Reply

Your email address will not be published. Required fields are marked *